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[1] Systematic reviews and meta-analyses of randomized controlled trials report that retatrutide produces substantial reductions in body weight in adults with obesity, with mean percentage weight loss typically between 15 and 24 percent over 48 to 72 weeks, depending on study protocols and populations

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The Frontiers review suggested building toward 30 to 60 minutes of daily aerobic activity

There was a significant average paired fold change in the levels of several GPs 1 week after 4-week intermittent fasting compared with the levels before 4-week intermittent fasting (Supplementary Table S2)