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We further demonstrate that activation of both mTOR-STAT3 and ERK-CREB pathways, induced by elevated circulation amino acids, is responsible for upregulation of Vgf and Gcg expression following glucagon receptor blockade

10.1001/jama.2014.11011 JAMA 51 HoppeC.JacobE.StylesL.KuypersF.LarkinS.VichinskyE

These data come from Cosmos, a dataset created in collaboration with a community of Epic health systems representing more than 256 million patient records from 1,400 hospitals and more than 32,800 clinics from all 50 states and Lebanon

Abdelwahab MG, Fenton KE, Preul MC, Rho JM, Lynch A, Stafford P et al

However, neonatal developmental influences can also be fairly subtle and still have pronounced effects