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Abbreviations AD Alzheimers disease ALS Amyotrophic lateral sclerosis APOE Apolipoprotein E ATP adenosine triphosphate HB beta-hydroxybutyric acid FA fatty acids GABA gamma-amino butyric acid KB ketone bodies KD Ketogenic diet MAD Modified Atkins diet MCT medium-chain triglyceride MS multiple sclerosis PD Parkinsons disease PEO progressive external ophtalmoplegia PPAR peroxisome proliferator activated receptor PUFA polyunsaturated fatty acids RCT randomized controlled trial ROS reactive oxygen species SGLT2 sodium-glucose cotransporter-2 UCP uncoupling proteins VLCKD very-low-carbohydrate ketogenic diet

[1] Rheumatoid arthritis, affecting an estimated 18 million individuals globally, further amplifies demand as biologic therapies such as adalimumab and etanercept are increasingly commercialized in prefilled syringe and autoinjector configurations that support both clinical and home administration