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In physiciansupervised settings, BPC157 and TB500 have shown favorable safety profiles in preclinical and early clinical use, with most side effects being mild and transient (such as temporary injectionsite irritation or mild digestive changes)

B12 injections are medically indicated for individuals with a diagnosed B12 deficiency or conditions that impair B12 absorption, such as pernicious anemia, Crohns disease, celiac disease, or a history of gastric bypass surgery

The July 23, 2026 Pharmacy Compounding Advisory Committee votes concerning BPC-157-related and TB-500-related substances were nonbinding recommendations