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First, we documented that our siRNA approach reduced Mtpa mRNA levels by 76% and MTP protein by 67% in caSMCs and compared the results with those obtained with the negative control siRNA (Figure 7, A and B)

MDR-001 is a novel, orally bioavailable small-molecule GLP-1R agonist discovered using MindRanks proprietary AI platform, Molecule Pro

In addition to GLP-1, this class of GPCRs includes receptors for glucagon and GIP, which are intrinsically linked to the pathophysiology or various treatment aspects of diabetes (6365), and GLP-2 receptors that have been identified as the basis for a new treatment for short bowel syndrome (66)

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