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Existing findings indicate that the protective mechanism is mainly attributed to the GLP-1 signaling pathway, which involves cyclic adenosine monophosphate (cAMP), protein kinase A (PKA) and cAMP response element-binding protein (CREB)

In contrast, the fact that nausea and vomiting are symptoms experienced by a minority of patients after RouxenY gastric bypass surgery (Scarpellini et al., 2020) might suggest that in situations of strongly increased GLP1 release, such as observed after RouxenY gastric bypass surgery, circulating GLP1 levels can become sufficient to elicit nausea and food intake effects

Impact of glucagon-like peptide-1 receptor agonists on the incidence of atrial fibrillation

Absolute risks are relatively low, but worth understanding before starting, especially for lifelong use