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And here is a detail that gets overlooked constantly: participants who received an initial starting dose of 4 mg experienced more GI symptoms than those who started at 2 mg

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Short-term sleep deprivation increases intrinsic excitability of prefrontal cortical neurons

In summary, the microbiota is not a passive player in the gutbrain axis but a dynamic regulator that communicates with the CNS through immune, endocrine, metabolic, and neural signals

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