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Activation of GLP-1R markedly reduced the levels of pro-apoptotic Bax and cleaved-caspase3, and increased anti-apoptotic Bcl-2 in IL-1-induced chondrocytes, indicating that GLP-1R may be a potential target for the treatment of OA

Additionally, resveratrol was able to decrease the activation of microglia in the hippocampal dentate gyrus as well as hippocampal levels of NLRP3, and NF-kB increased by estrogen deficiency