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A mismatch can develop between the haptocorrin-bound pool, which makes up most of the total, and the smaller active fraction on transcobalamin that cells depend on

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C.YuJ.HuX.HanX.et al (2022)

Nasal Spray Storage Requirements Optimal Conditions : Temperature : Refrigerate at 36-46F (2-8C) for liquid formulations Light exposure : Store in original amber bottle to protect from UV degradation Humidity : Keep away from excessive moisture Shelf life : 60-90 days once reconstituted