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Bailey LB, Gregory JF, 3rd

In ME/CFS, this protective mechanism is severely compromised

Not for human or veterinary therapeutic use

In addition to the two aforementioned oral-specific environmental resistance factors, the clinical translation of nanomaterials currently faces several challenges:(1) the long-term biosafety, biocompatibility, and functional durability of these nanomaterials within the oral cavity require rigorous assessment in live animal models and, ultimately, clinical trials (Sajithkumar et al., 2025)

The clinical trial pathway for a new therapeutic agent is a multi-stage process designed to rigorously evaluate its safety and efficacy before market release