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While dipeptidyl peptidase-4 (DPP-4) inhibitors, including saxagliptin and linagliptin, have proven kidney benefits for patients with T2D and CKD, we chose GLP-1 RAs as the active comparator in this study because (1) they share similar pleiotropic effects with SGLT2 inhibitors, such as cardio-kidney and metabolic impacts

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When that effect weakens, you notice it in specific ways