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The occurrence of ferroptosis depends on multiple parallel and coupled molecular pathways, and the role of GPX4 within them is strictly constrained by upstream reductive systems, lipid substrate sources, and alternative antioxidant networks

DAS transiently increases ROS concentrations stimulating, ERK and P38 MAP kinase which phosphorylate Nrf2 [203, 220]

There was no difference between groups for age, disease duration, or the number of patients having FM