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Timestamps 00:00 Cold open: Danny Cahill and The Biggest Loser 01:03 What we mean by "willpower" 05:48 Obesity tripled in ~60 years: the one number 06:31 Adoption and twin studies: genes vs

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The World Health Organization's December 2025 guidelines emphasized the importance of resistance training to protect muscle mass during GLP-1 therapy, acknowledging this as a limitation of current treatment approaches [49]