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It most commonly begins in middle age, often between 30 and 60 years old

investigated the genetic association between 35 single-nucleotide polymorphisms (SNPs) and an I/D polymorphism in the ACE gene

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Etheresia Pretorius, orcid.org/0000-0002-9108-2384 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers