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Some people report feeling bloated even when dealing with loose stools

As previously mentioned, GLP-2 increases intestinal blood flow and stimulates the expression of intestinal endothelial nitric oxide synthase (eNOS) (Guan et al., 2003)

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Metformin has been shown to have some anti-inflammatory effects in clinical studies in patients with T2DM, in experimental studies in rodent models of obesity and T2DM, and in vitro experiments with several immune cells (Foretz et al., 2019