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Most of my patients are surprised at how simple it is

Lancet 391 (10140), 26072618 (2018)

Since then, several others have followed, including dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), semaglutide (Ozempic, Wegovy), and the latest FDA-approved medication, tirzepatide (Mounjaro, Zepbound)

It has been shown that patients with major depressive disorder have systemic and localized disorders of glucose metabolism throughout the course of the disease, disrupting various processes such as glucose uptake, glycoprotein transport, glycolysis, the tricarboxylic acid cycle and oxidative phosphorylation