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Both require a prescription and medical supervision

These gastrointestinal symptoms typically decrease as your system becomes accustomed to GLP-1 signaling, and many patients experience no adverse effects beyond mild nausea during dose escalation

NICE guidance does not mandate preference for daily versus weekly formulations but recommends individualising treatment choice based on patient factors including: Lifestyle and convenience : Weekly injections may suit busy schedules Tolerability : Some patients experience fewer gastrointestinal side effects with certain formulations Clinical efficacy : Specific medications may provide better glucose control or weight loss for individual patients Cost-effectiveness : NHS formularies may influence availability Your GP or diabetes specialist nurse will discuss which dosing schedule best suits your circumstances, taking into account your treatment goals and personal preferences

The supernatant was then transferred into HPLC vials and stored at -80 C until further analysis