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Excess histamine can also damage the glycocalyxthe protective layer covering cellsleading to inflammation, gut dysbiosis, and higher risks of cardiovascular disease, diabetes, kidney disease, and stroke

On the other hand, it is also clear that prolonged LC supplementation elevates fasting plasma TMAO [16,17,18, 58, 59], compound supposed to be pro-atherogenic [61]

Loss of weight from GLP-1 agonists may also help with psychological hindrances to libido, like low self-esteem from previous stigmatization

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The SURMOUNT program also generated important data on metabolic health improvements beyond weight loss