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These metabolite changes suggest that the retrograde signal may involve altered activity of chromatin-modifying enzymes sensitive to these metabolites

10.1172/JCI163669 134 PietrangeloT.FulleS.CosciaF.GigliottiP

Close up to ulceration within the diverticulum Colonoscopy revealed several large diverticula, the largest of which had an approximate 8 cm os and surrounding erythematous and friable mucosa that was biopsied showing ulcer debris and evidence of diverticular colitis

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