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Either the overproduction of the Fe 2+ that is involved in the formation of lipid hydroperoxides through the Fenton reaction 111 or the inactivation of glutathione peroxidase 4, which is programmed to degrade lipid hydroperoxides, leads to intracellular lipid hydroperoxide accumulation to a lethal level, ultimately triggering ferroptosis 112

This ratio is contrasted with the roughly equal sex distribution of cutaneous melanoma

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Each sample was divided into 3 portions, one for estimation of each enzyme and was stored at 80C till assay

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