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Incidence rate ratios (IRRs) of malignancy in patients with type 2 diabetes mellitus (DM): glucagon-like peptide-1 receptor agonist (GLP-1 RA) group vs

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GLP-1RA treatment enhances IL-10 secretion by M2 macrophages (133), an effect that exhibits strong concentration dependence: Low IL-10 concentrations may facilitate tumor immune evasion, whereas high concentrations promote CD8+ T cell proliferation, activation and cytotoxicity (134)