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Vitamin D, particularly in its salivary form, is increasingly recognized as a non-invasive biomarker indicative of both systemic and oral immunity, maintain calcium homeostasis, facilitating antimicrobial defence, and modulating periodontal inflammation

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In addition, another study discovered that PA can significantly alter the histone H3K4me3 levels at the promoters of the cellular genome through the stable deposition of the methyltransferase Set1A (a member of the MLL/COMPASS family) [53]

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