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Free radicals, unstable molecules produced through exposure to environmental pollutants, UV radiation, and even stress, contribute significantly to skin aging

Older immune cells become less effective at identifying and clearing pathogens and abnormal cells

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By the mid-2000s, the obesity pharmacotherapy field expected at least 5% placebo-subtracted weight loss for regulatory consideration, a threshold later codified in FDA's 2007 guidance for industry on developing obesity drugs

doi: 10.12659/MSM.947531 176 ChenSLuZHuangQZhaoGSunZZhouJet al