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Mucus comprises a variety of mucin glycoproteins released by goblet cells in the intestine and can extend up to 150 meters from the colonic epithelium ( The gut microbiota has been shown to promote the formation of antimicrobial proteins (AMP) such as cathelicidins, C-type lectins, and (pro)defensins by host Paneth cells through a PRR-based pathway involving its structural components and metabolites (Salzman et al., 2007