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We developed the measures for this ASM performance category based on our review of feedback provided in response to our RFI (89 FR 61596), interviews with interested parties, and an environmental scan of existing practice coordination activities from the Quality Payment Program and other Innovation Center models

In conclusion, we observed in vitro that, in APAP-induced hepatotoxicity, released HMGB1 from damaged hepatocytes contributed to the propagation of necrosis by a direct effect on neighboring hepatocytes in a feed-forward circuit

Whether G6PD regulates MAPK and p53 signaling pathways remains to be addressed in future studies

2.5 Statistical analysis We pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) using the DerSimonian and Laird random-effects model, which accounts for between study heterogeneity

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