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Targeting allosteric regulation of cancer metabolism

Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135137]

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In older adults relative to young + middle-aged adults, they found higher GSH levels in the frontal cortex and higher GSSG levels in the caudate (Tong et al., 2016)

The infusion takes about 30 to 45 minutes