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Theres growing evidence in animal models that the drugs make it through the blood-brain barriera protective membrane surrounding most of the organby penetrating leaky areas, such as the NTS

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However, these interventions are often used as adjunct therapies, and their clinical efficacy may be inconsistent due to individual differences and complex mechanisms

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In most cases the cause of the disease is unknown (idiopathic), although a genetic cause is suspected in most cases of pediatric RCM