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The supplement helps to combat the decrease in the production of glutathione with age

NAC also functions as a direct antioxidant through its free thiol (-SH) group, scavenging reactive oxygen species independently of the glutathione pathway

However, modern advancements in supplement formulation have significantly improved the bioavailability of oral B12, making it a more effective option than ever before

Without addressing that rate-limiting step, supplementation fails, no matter how much of ingredient X you consume

Regardless of the precise mechanism of the association between RA and ESRD, it seems prudent that RA patients who are relatively young and healthy (i.e., without other comorbid conditions) should be prioritized to be managed by a kidney-protective treatment strategy, such as biologic agents