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The mechanisms regulating bone remodeling are more complex and involve a greater number of factors (Robling et al., 2006)

Sex, race, and smoking history have no clinically significant influence on plasma concentrations of donepezil [4651]

The immune system hypothesis includes the alteration of the proper functioning of the central nervous system (CNS) associated with an abnormal response to common antigens, stimulation of the inflammatory and cell-mediated immune responses, and upstream regulation of oxidative and nitrosative pathways, and autoimmune responses against neuronal and other cells (Marshall-Gradisnik et al

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Thus, identifying novel therapeutics that target multiple pathways and genes associated with AD represents a promising strategy for treatment