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Whilst there is no established direct mechanism by which GLP-1 receptor agonists consistently cause joint pain, several indirect factors may explain why some patients experience musculoskeletal discomfort during treatment

By helping your body use insulin more effectively, you can prevent excess fat storage, helping you lose weight more efficiently

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More recently, encouraging clinical results from a triple-hormone-receptor agonist, Retatrutide, and several GLP-1R/GCGR dual agonists, suggest that GCGR could be a promising co-stimulating target for type 2 diabetes and obesity

Effect of Glucagon-like Peptide 1 on Salivary Gland Hypofunction in Diabetic Db/Db Mice. Journal of Biomedical and Translational Research , vol