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The largest psychiatric meta-analysis to date 80 randomized controlled trials, over 107,000 patients also found significant improvements in restrained eating and emotional eating with GLP-1 medications compared to placebo ( Pierret et al., JAMA Psychiatry, 2025 )

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As more specialized practices add GLP-1 programs using semaglutide and tirzepatide, documentation, tracking, and protocol management are becoming operational issues, not just clinical ones

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