Its not clear why a substantial minority of individuals dont lose weight when taking a GLP-1 this is a question of tremendous scientific and clinical importance. His own recent study in JAMA Internal Medicine suggests that the drugs work similarly across patient groups based on factors such as age, race, and whether people have diabetes, but he said its entirely plausible that there are genetic determinants of GLP-1 effectiveness that have yet to be identified. For years, personalized medicine has been one of the biggest buzzwords in health care, heralding a new era in which treatments are not one-size-fits-all, but matched to a persons biology
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A paracrine relationship exists between GLP-1-secreting L cells and somatostatin-secreting D-cells (Jepsen et al., 2019)
