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Low glutathione levels are associated with chronic inflammation, mitochondrial superoxide production and oxidative protein / DNA damage

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However, benchmarking against SUSTAIN-6 flagged disagreement for the effect on all-cause mortality, highlighting potential residual confounding for this secondary endpoint that could reflect preferential prescribing in patients for whom clinicians anticipated limited life expectancy

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Zagon IS, Mclaughlin PJ (2017) Endogenous opioids in the etiology and treatment of multiple sclerosis