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Barnabei L, Laplantine E, Mbongo W, Rieux-Laucat F, Weil R

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It is a gel-like polysaccharide/protein complex that is synthesized by endothelial cells and is rich in heparan sulfate (HS)

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Its physiological actions include: Increasing glucose-dependent insulin secretion Suppressing glucagon release Delaying gastric emptying Reducing appetite and caloric intake Enhancing satiety Improving insulin sensitivity Promoting weight reduction The major limitation of native GLP-1 is its ultra-short half-life due to rapid degradation by DPP-4 enzymes

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