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One study found that Rb inhibits the expression of SLC1A5 and the activity of GLS1 by regulating E2F-3, consequently blocking the intake and metabolic processing of Gln

In KCs, SIRT1 deacetylates the NF-B p65 subunit, inhibiting its transcriptional activity and reducing the expression of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6

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