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It was first identified as a factor that accelerated wound healing, but research quickly expanded to show roles in collagen stimulation, angiogenesis, and gene expression
Springer, Singapore
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In one embodiment, when one or more buffers are utilized in the formulations of the present disclosure, they are combined, e.g., with a pharmaceutically acceptable vehicle and are present in the final formulation, e.g., in an amount ranging from about 0.1% to about 20%, from about 0.5% to about 10%