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Early-phase clinical trial data, including results from a Phase 2 trial published in The New England Journal of Medicine in 2023, demonstrated substantial weight reductions in some participants exceeding 20% of body weight over 48 weeks alongside a broadly manageable short-term adverse effect profile

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In autoimmune thyroiditis, inflammasome activation is modulated by the microRNA-612/BRD4 axis, while LINC01061 enhances the inflammatory activity of thyroid follicular epithelial cells

Clinical trials ran for 68 weeks (approximately 16 months), with participants losing an average of 14.9% of total body weight