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The metabolite-to-parent ratios of noroxycodone and noroxymorphone decreased by 44% and 45% respectively

Although it has been demonstrated in mammals, such as rodents and dogs, that serine can be converted to pyruvate through a deamination reaction catalyzed by the vitamin B6-dependent enzyme, serine/threonine dehydratase (encoded by the SDS gene), the serine deamination activity of the enzyme appears to be lacking in humans even though the activity is involved in the catabolism of threonine in humans as described in the Threonine Catabolism section below

About two-thirds of participants had prediabetes at baseline

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Wilson L, Stewart W, Dams-OConnor K, Diaz-Arrastia R, Horton L, Menon DK, et al