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While safety data is encouraging, with no significant differences in adverse events compared to placebo, a larger Phase IV outcomes trial is ongoing to confirm the long-term cardiovascular benefits of enlicitide, and Merck has initiated the FDA approval process, with the drug in the fast track program

Other symptoms of deficiency may include inflammation, headaches, skeletal disorders, and nearsightedness

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In older persons, walking discomfort, functional impairment, and lower satisfaction scores are linked to elevated inflammatory markers such as C-reactive protein (CRP)