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Inducible nitric oxide synthase and CD11b+Gr1+ Cells impair lymphatic contraction of tumor-draining lymphatic vessels

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Abbreviations AIH: Autoimmune hepatitis ALF: Acute liver failure ALT: Alanine aminotransferase APAF-1: Apoptotic protease activating factor-1 APAP: Acetaminophen (N-acetyl-p-aminophenol) AREs: Antioxidant response elements ASH: Alcoholic steatohepatitis ASMA: Anti-smooth muscle antibodies AST: Aspartate aminotransferase ATP: Adenosine triphosphate BAs: Bile acids Bcl-2: B-cell lymphoma 2 BSEP: Bile salt export pump CABP: Community-acquired bacterial pneumonia CD8 +: Cluster of differentiation 8 positive CD20 +: Cluster of differentiation 20 positive CIOMS: The council for international organizations of medical sciences CT: Computed tomography CTLA-4: Cytotoxic T-lymphocyte-associated protein 4 CXCL10: C-X-C motif chemokine ligand 10 CYP2C8: Cytochrome P450 2C8 CYP2C9: Cytochrome P450 2C9 CYP3A4: Cytochrome P450 3A4 CYP3A5: Cytochrome P450 3A5 CYP450: Cytochrome P450 DAMPs: Damage-associated molecular patterns DAAs: Direct-acting antivirals DDW-J: Digestive disease week Japan DILI: Drug-induced liver injury DNA: Deoxyribonucleic acid DR5: Death receptor 5 ER: Endoplasmic reticulum Fas: Fas cell surface death receptor FasL: Fas ligand FADD: FAS-associated death domain protein GR: Glutathione reductase GSH: Glutathione GGT: GGT: Gamma-glutamyl transferase GWAS: GWAS: Genome-wide association studies HAV: Hepatitis A virus HBV: Hepatitis B virus HCV: Hepatitis C virus HDS: Herbal and dietary supplements HEV: Hepatitis E virus HLA: Human leukocyte antigens HMGB-1: High-mobility group box-1 HO-1: Heme oxygenase-1 HPLC: High-performance liquid chromatography HSV: Herpes simplex virus IgG: Immunoglobulin G IL-1: Interleukin 1 beta IL-6: Interleukin 6 IL-8: Interleukin 8 ICI: Immune checkpoint inhibitor IRE1: Inositol-requiring enzyme 1 alpha JNK: C-Jun N-terminal kinase Keap1: Kelch-like ECH-associated protein 1 LC3: Microtubule-associated protein 1 light chain 3 LogP: Logarithm of the partition coefficient LTT: Lymphocyte transformation test MAPK: Mitogen-activated protein kinases MDR: Multidrug resistance mPTP: Mitochondrial permeability transition pore MRCP: Magnetic resonance cholangiopancreatography MRP2: Multidrug resistance-associated protein 2 mRNA: Messenger ribonucleic acid NASH: Nonalcoholic steatohepatitis NAPQI: N-acetyl-p-benzoquinone imine NAFLD: Nonalcoholic fatty liver disease NF-B: Nuclear factor kappa B NKT: Natural killer T NOACs: Novel oral anticoagulants NSAIDs: Nonsteroidal anti-inflammatory drugs Nrf2: Nuclear factor erythroid 2-related factor 2 OAT: Organic anion transporter OATP: Organic anion transporting polypeptide OCT: Organic cation transporter p53: Tumor protein 53 PERK: Protein kinase R-like endoplasmic reticulum kinase PNH: Paroxysmal nocturnal hemoglobinuria PTPN22: Protein tyrosine phosphatase non-receptor type 22 ROS: Reactive oxygen species RUCAM: Roussel Uclaf Causality Assessment Method SDH: Succinate dehydrogenase TNF-: Tumor necrosis factor alpha TRAIL: TNF-related apoptosis-inducing ligand ULN: Upper limit of normal UPR: Unfolded protein response References Suh JI (2020) Drug-induced liver injury

Conclusion The described results show that, after the optimization of enzyme kinetics measurement conditions, the GP activity of pregnant rats is clearly distinct by the GP activity of female age paired nulligravid animals