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Utilizing fluorescein-labeled peptide, analysis of dual receptor agonists, exendin-4 and liraglutide, identified that agents with higher BBB permeability have improved protective effects, with DA5CH showing the highest efficacy [109, 110]

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Intriguingly, although SF3B1 does not possess a direct role in MAPK pathway signal transduction, there is little overlap between tumors with MAPK pathway mutations and SF3B1 -mutated tumors, suggesting that SF3B1 mutations possibly lead to splicing variations of specific genes that can lead to MAPK activation (118)

Brito, S

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