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4.6 Rheumatoid arthritis Rheumatoid arthritis (RA) is a systemic autoimmune disease that results in progressive joint destruction due to the infiltration and proliferation of immune cells in the synovium (93)

By incorporating checkpoint inhibitors (e.g., anti-PD-1/PD-L1 antibodies), cytokines, or innate immune activators such as STING agonists into hydrogel scaffolds, the suppressive cervical TME can be actively reprogrammed into a pro-inflammatory and immunostimulatory state [62,63,64]

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