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The work benefited from the support of the Animal Breeding and Housing facility (S

Working closely with medical staff and plastic surgeons helps ensure a seamless surgical experience for the patient

Intracellular signaling and secondary pathways MC1R-MC5R receptor activation primarily couples Gs but also recruits, to varying extents depending on the receptor and agonist, other pathways: Gq (phospholipase C, IP3, calcium), Gi under certain conditions (notably MC3R), and the ERK1/2 MAP kinase pathway via arrestin and EGFR transactivation

No major clinical guideline prohibits it

This article will be updated when peer-reviewed publications become available.