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10.1016/S0140-6736(19)31271-1 Summary Keywords colorectal cancer, gastrointestinal cancer, GLP-1 receptor agonists, liver cancer, meta-analysis, obesity, oncological safety, pancreatic cancer Citation Wali AF, Rangraze I, Khan S, Mufti UB, El-Tanani M and Rizzo M (2026) Reassessing cancer risk with GLP-1 receptor agonists: a comprehensive meta-analysis of gastrointestinal malignancies

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In preclinical studies, PEG liposomes loaded with glial cell line-derived neurotrophic factor (GDNF) delivered via FUS markedly improved motor performance, illustrating the synergistic potential of combining nanomedicine with FUS-mediated BBB disruption [292]

In this context, GLP-1 RA therapy does not introduce a novel mechanism of harm

For behavioral studies, data were analyzed by ANCOVA, or repeated-measures one-way or two-way ANOVA followed by Tukeys or Bonferronis post hoc test as appropriate