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Rationale : Obesity is a global health challenge with few pharmacologic options

It is not intended for type 1 diabetes or diabetic ketoacidosis and is not a substitute for insulin

Medicare coverage for GLP-1 medications expanded in 2024 to include semaglutide for weight management in adults with obesity, which may indirectly benefit some prediabetic beneficiaries

In this paper, we report five cryo-EM structures of two well-recognized multi-targeting agonists (tirzepatide and peptide 20) in complex with individual receptors and G s proteins