This discrepancy could be attributed to the presence of various metabolites, including GSH in UDE, which may have contributed to cytotoxicity
The beneficial effects of GLP-1 RAs on HRQoL and other outcomes in HFpEF are likely due to pleiotropic impacts, related or not to weight reduction, such as decongestion (mainly due to the reduction of increased plasma volume associated with obesity and epicardial constrain), reverse cardiac remodelling (mainly due to the decrease in epicardial fat and regression of left atrial and LV myopathy, lowering intracardiac pressure) and anti-inflammatory actions, among others
Here, we found that NAC promotes protein aggregation, but the synergistic effects of NAC and different antibiotics vary
Nat Rev Neurol 2023, 19: 235245
This is one of the most important (and often overlooked) pieces of the puzzle, especially when it comes to preventing relapse