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Consequently, it aids in weight loss
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It cleaves the oligo-peptides after the 2nd amino acid from the N terminal proline or alanine sequences, thus rendering GLP-1 and GIP inactive ( in vivo through dipeptide cleavage (Mentlein et al., 1993)
491 By regulating appetite, insulin secretion, and lipid metabolism, GLP-1RAs have potential benefits in the treatment of NAFLD, NASH, and T2DM
Patients with A1C 8% at screening reduced the insulin dose by 20% at the start of the trial to reduce the risk of hypoglycemia
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