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I think that jury is still out. Its possible that GLP-1s are affecting the brain and body in ways that researchers dont yet fully understand

In addition, fucoxanthin has been found to improve glucose and lipid metabolism, increase the use of fats for energy, and regulate adipose tissue function

Demonstration of a functional motilin receptor in TE671 cells from human cerebellum

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Study 4 was a 68-week trial that enrolled 611 patients with obesity (BMI greater than or equal to 30 kg/m2) or with overweight (BMI 27-29.9 kg/m2) and at least one weight-related comorbid condition such as treated or untreated dyslipidemia or hypertension