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These picomolar levels of 15-HpETE-PE alone (Supplemental Figure 4A, generated under IL-13 plus arachidonic acid conditions) would be insufficient to directly oxidize the nanomolar changes caused by oxidation of GSH to GSSG observed in response to IL-13 (or the change with inhibition of 15LO1 or KD of ALOX15 /15LO1)

showed that supplementation with Bifidobacterium longum NCC3001 (BL) at a dose of 1 10 10 CFU/day for 4 weeks improves depression-like symptoms (reduced BDI-II score by 3.2 points) and quality of life (increased IBS-QoL score by 15%) in IBS patients with comorbid depressive symptoms (20)

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Effect of hypotonic 0.18% sodium hyaluronate eyedrops on inflammation of the ocular surface in experimental dry eye