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Proteinase K and nargase prefer cleavage at aromatic and aliphatic amino acid side chains at position P1, while trypsin favors cleavage at a positively charged amino acid like Arg and Lys at position P1

Given the strong relationship between ROS and cell death, regulating ROS generation upward or controlling oxidative defense downward has become central for new cancer treatments, which have been enhanced by the finding that cancer cells process a higher level of ROS than do healthy cells (Galadari et al., 2017)

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10.1016/j.cell.2025.01.023 69 YangC.LiuS.MiaoJ.MouQ.LiuX.WangP.et al (2021)

A hormone is a messenger